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Summary
The Cell Stress & Death Lab investigates the molecular mechanisms of ferroptosis—a newly characterized, iron-dependent form of regulated cell death—and its critical interplay with Endoplasmic Reticulum (ER) Stress. It plays a central role in numerous diseases, including cancer, stroke, metabolic and neurodegenerative disorders. This research explores the molecular mechanism of ferroptosis, how it contributes to disease pathogenesis and how it is influenced by ER stress and the Unfolded Protein Response (UPR).
The Group is particularly interested in how dysregulation of ferroptosis and ER stress pathways drives disease progression, shapes the cellular response to therapy, and influences long-term tissue function. Understanding these interactions could uncover new biomarkers and therapeutic targets for treating stress-related diseases.
To dissect these complex cellular processes, the lab utilizes:
• in vitro models to analyze molecular mechanisms (2D & 3D)
• ex vivo systems for studying tissue-level dynamics (e.g., GEVS)
• in vivo animal models to understand physiological outcomes.
This integrated approach allows to capture a comprehensive view of how ferroptosis and ER stress operate in both healthy and diseased states. By advancing knowledge of these interconnected stress pathways, the Group aims to develop novel strategies for manipulating cell death in a controlled way—offering potential breakthroughs in the treatment of diseases driven by cellular dysfunction.
Keywords
Cell Death – Ferroptosis; ER Stress & UPR; Cancer; Autoimmune Diseases.
Publications
Group members
Group Leader
Researcher (RTDa)
Post Doc Research Fellow
Emanuele Ferrario
PhD Student
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